Abstract: Objective: To determinate the concentration of adenosine deaminase(ADA)、β₂-microglobulin(β₂-MG) and saliva acid(SA) in patients withsevere acute respiratorysyndrome(SARS) and evaluate the immunore-action and degree of damage caused by severe acute respiratory syndrome virus.Method Serumsamples of thepatients with SARS,pulmonary tuberculosis(TB) or normal pneumonia(NP) were collected and the levels ofADA、β₂-MGand SAwere detected separately.Results(1)As to the ADAlevel,SARS group was obviouslylower thanthe TBgroup(P<0.001) while among SARS patients,the result was different withthe total amountof WBChigher or lower than 5.0×109/l in which the higher group has more ADAproduction than the lowergroup.(2)As totheβ₂-MGlevel,SARS group was higher thanthe TBgroup or the NPgroup while it rise withthe age inthe SARS patients.(3)The SAconcentrationinthe SARS group was higher thanthe TB group or theNPgroup while the result was different withthe total amount of WBChigher or lower than 3.0×10⁹/Lin whichthe lower group patients produced more SAthanthe higher group.Discussion: The concentration of ADA、β₂-MGand SAcan be used as a set of parameterto evaluatetheimmunoreactionand degree of damage caused byse-vere acute respiratory syndrome virus.

Key words: SARS, ADA, β₂-MG, SA