Abstract: Objective To evaluate the clinical outcome and safety of the treatment of multi-drug resistance cavitary pulmonary tuberculosis with drug gel by fiberbronchoscope.Methods 204 patients of cavitary pulmonary tuberculosis were included in the study.108 patients of them treated with drug gel by fiberbronchoscope and anti-tuberculosis treatment were classified into the experiment group.96 patients treated anti-tuberculosis treatment were classified into the control group.20 mg of the gel used in the experiment group contains pasiniazid 600 mg,streptomycin 1000mg,pyrazinamide 500mg and L-ofloxacin 400mg.Sputum negative conversion rate,tuberculose focus treatment effective power,tuberculous cavity treatment effective power,complication and adverse reaction of all patients at the 6th,12th and 18th month post-treatment were observed.Results Sputum negative conversion rate in the experiment group were 51.9%,79.6% and 88.9% at the 6th,12th and 18th month post-treatment respectively,which were higher than those in the control group.Tuberculose focus treatment effective power in the experiment group were 52.8%,81.5% and 90.7%,tuberculous cavity treatment effective power were 50.9%,79.6% and 89.8% at the 6th,12th and 18th month post-treatment respectively,which were higher than those in the control group too.Complication and adverse reaction of patients in the two groups had no significant difference.Conclusions The clinical outcome and safety of the treatment of multi-drug resistance cavitary pulmonary tuberculosis with drug gel by fiberbronchoscope are better than those of the routine anti-tuberculosis treatment.

Key words: tuberculosis, gel, multi-drug resistance