Abstract: Objective To determine the incidence of HIV/AIDS co-infection among inpatients with tuberculosis in a hospital-based sentinel site in Hunan province. Methods The inpatients with tuberculosis were consecutively enrolled and screened for HIV infection using ELISA assay over 3 year period.Positive Results were repeated by a second HIV ELISA testing and confirmed by a western blotting.Results Total 3345 eligible tuberculosis patients were admitted and screened for HIV test during 3 years observation period,2257(67.5%) were male and 1088(32.5%)were female with the mean age(SD) 41.1(±13.0) years.64.5% of them were farmers,24.6% were staff and workers,10.1% were commercial servers and the rest were students in high school or college.3274 of the participants(97.9%) were diagnosed as pulmonary tuberculosis,50 tuberculous pleurisy and 21 extra-pulmonary tuberculosis cases.Of pulmonary tuberculosis cases,598(18.3%) were sputum smear positive for acid-fast bacilli and 2676(81.7%) were negative,1057(32.3%) were new cases and 2217(67.7%) retreatment cases.Total 2 cases with pulmonary TB were confirmed HIV-seropositive,both were male with the age of 49 and 40,respectively.They was infected HIV by sexual transmission.HIV/AIDS incidence among inpatients with tuberculosis was 0.06%.Conclusions The incidence of HIV/AIDS among inpatients with tuberculosis in a hospital-based sentinel site approximates 0.05%,which was estimated among general population.

Key words: HIV/AIDS, Tuberculosis, Sentinel surveillance