Immune checkpoint inhibitors and tuberculosis

doi:10.19982/j.issn.1000-6621.20250014

Abstract

Abstract:

The emergence of immune checkpoint inhibitors (ICI) has revolutionized the landscape of cancer treatment, bringing new treatment hope to patients with advanced and refractory cancer. However, with the broad clinical application of ICI in the treatment of cancer, immune system-related complications, particularly, the emergence of tuberculosis (TB), has become a growing concern. The author aims to systematically summarize the incidence of TB and potential mechanisms in cancer patients receiving ICI treatment, providing novel insights for TB screening and clinical management before ICI treatment in cancer patients.

Key words: Neoplasms, Immunotherapy, Immunologic factors, Immunosuppressive agents, Tuberculosis

CLC Number:

R521.2

Qi Qi, Wang Zihao, Ye Linlin, Peng Wenbei, Zhou Qiong. Immune checkpoint inhibitors and tuberculosis[J]. Chinese Journal of Antituberculosis, 2025, 47(6): 792-797. doi: 10.19982/j.issn.1000-6621.20250014

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