Abstract:

A total of 186 cases with T2DM-PTB who were admitted to the Tuberculosis Department of Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine (The Second Hospital of Nanjing, Nanjing Public Health Medical Center) from January 2018 to June 2018. One hundred and sixty-five patients who met the inclusion criteria were numbered, and 55 of them were selected as the T2DM-PTB group by systematic sampling method. In addition, 815 age-matched patients with pulmonary tuberculosis in our hospital were screened, and 55 of them were selected as the PTB group by systematic sampling method. The serum levels of IL-6 and CRP were tested, and examination of sputum smear for acid-fast bacilli was conducted. The numbers of lesions were counted for statistical analysis. The results showed that media (quartile) M(Q₁,Q₃) levels of serum IL-6, CRP, and the lung lesion rang of T2DM-PTB group were (21.2 (21.2,44.4) ng/L, 31.2 (15.1,77.3) mg/L, and 4.0 (3.3,6.0)) respectively, which were higher than those of PTB group (8.6 (8.6,19.2) ng/L, 13.5 (4.5,37.4) mg/L, and 3.0 (3.0,4.0); there were significant differences among the two groups (U=3.78, 3.45, and 2.45; P=0.000, 0.001, and 0.014). The media (quartile) M(Q₁,Q₃) number of sputum examination positive cases in the T2DM-PTB group was higher than that in the PTB group (1.5 (0.0,5.8) vs 0.0 (0.0,2.0)), but the difference was not statistically significant (U=1.74, P=0.083). In conclusion, compared with PTB patients, T2DM-PTB patients had higher levels of IL-6 and CRP and wider lung lesion ranges, suggesting more active inflammatory state in the patients suffering PTB and T2DM.

Key words: Tuberculosis,pulmonary, Diabetes mellitus,type 2, Comorbidity, Interleukin-6, C-reactive protein, Discriminant analysis