Abstract: Objective To understand the situation of drug resistance(DR)and multi drug-resistance(MDR-TB)tuberculosis in Shenzhen and provide scientific evidence for TB control in Shenzhen.Methods According to drug resistance TB guidelines issued by WHO/IUALD,all new smear positive cases and new registered retreatment smear positive cases from 1999 to 2008 were included in the surveillance.A total of 6702 strains of Mycobacterium tuberculosis were isolated and drug susceptibility test were performed with t...