Abstract: Objective To evaluate the diagnostic value of tuberculosis antibody, CRP, ESR, PPD skin test, PCR and combined the five method in the diagnosis of retreated pulmonary tuberculosis. Methods Tuberculosis antibody were measured by DIGFA (dot immunogold filtration assay), PCR by hybridization method, ESR by Westergram method, CRP by lmmunoturbidimetry Assay, and PPD skin test according to the national guideline. The sensitivity and specificity of single method and the diagnostic value of single and combined method were evaluated. Results The sensitivities of tuberculosis antibody, CRP, ESR, PPD skin test, and PCR were 92.0%,81.3%, 80.05,68.3%,66.7%, respectively;their specificities were 94.0%,87.0%,32.0%,72.0%,75.0%, respectively. In random combined 2 Methods the sensitivity increased markedly, the specificity of tuberculosis antibody combined with PCR was higher than that of other combinations(P<0.05).The sensitivities in combinations of 3 and more than 3 Methods reached approximately 100%,but their specificities decreased significantly. Conclusion The combination of tuberculosis antibody and PCR was more valuable among 5 methods. The other combination of more Methods couldn’t increase the diagnostic value for retreated pulmonary TB.

Key words: pulmonary tuberculosis/diagnosis, tuberculosis antibody, combined detection