Abstract: Objective To observe the pharmacokinetics of INH,RFP and OFLX in the serum of pulmonary tuberculosis patients with diabetes to provide references in choosing clinical therapeutic regimens.Methods 17 adult tuberculosis patients were randomly divided into two groups.The observe group,9 cases (pulmonary tuberculosis patients with diabetes);the control group,8 cases (non diabetes tuberculosis patients).They took INH 0.4,RFP 0.6,OFLX 0.6 orally.The concentrations of the three antituberculous drugs in the serum were measured by HPLC (high performance liquid chromatography).The data were calculated with software 3p87.Results There was significant difference in the T max of INH only ( P< 0.05).There was no significant difference between the two groups in the other pharmacokinetic parametres such as t _1/2 (h),C _max (μg/ml),AUC(μg/(ml·h)) of INH ( P> 0.05).There was no significant difference between the two groups in the t _1/2 (h),t _max (h),C _max (μg/ml),AUC(μg/ml· 1) of RFP( P > 0.05). There were significant differences between the two groups in the t _1/2 (h),T _max (h),C _max (μg/ml),AUC(μg/(ml·h)) of OFLX.Conclusion 1.INH and RFP,were not affected by the factors of diabetes,age and sex.2.OFLX,was affected by the factors of diabetes or age.

Key words: Tuberculosis,pulmonary, Diabetes mellitus, Antitubercular agents, Pharmacokinetics