Research progress of carbohydrate metabolism of Mycobacterium tuberculosis

doi:10.3969/j.issn.1000-6621.2020.08.018

Abstract

Abstract:

Mycobacterium tuberculosis (MTB) is generally believed to preferentially rely on lipid metabolism to both establish and maintain chronic infections. However, the metabolic network of MTB can simultaneously catabolize multiple carbon substrates. The versatility of metabolism has been increasingly considered as an important pathogenic mechanism. Carbohydrate metabolism occupies a significant position in the pathogenesis of MTB, and complete carbohydrate metabolism plays an important role in maintaining the steady state of MTB. Based on MTB carbohydrate metabolism as a clue, the author sorts out and analyzes the transport and generation of sugar in MTB as well as the functional enzymes during the catabolism process, and explores the mechanism of carbohydrate metabolism to assist MTB in maintaining the homeostasis, so as to provide scientific basis for the research and development of new anti-tuberculosis drugs.

Key words: Mycobacterium tuberculosis, Carbohydrate metabolism, Metabolomics, Research, Review

QU Meng-jin, LIANG Zheng-min, WANG Yuan-zhi, ZHOU Xiang-mei. Research progress of carbohydrate metabolism of Mycobacterium tuberculosis[J]. Chinese Journal of Antituberculosis, 2020, 42(8): 874-879. doi: 10.3969/j.issn.1000-6621.2020.08.018

Figures/Tables 3

References 46

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ABC糖转运蛋白	组成			底物	相关报道
ABC糖转运蛋白	底物结合蛋白	疏水跨膜结构域	核苷酸结合结构域	底物	相关报道
UgpABCE	UgpB	UgpA和UgpE	UgpC	甘油磷酸胆碱	文献[13]
LpqY-SugABC	LpqY	SugA和SugB	SugC	海藻糖	文献[14]
UspABC	UspC	UspA和UspB	未知	氨基糖	文献[15]
Rv2038c-Rv2041c	Rv2041c	Rv2039c和Rv2040c	Rv2038c	未知	文献[16]