Abstract:

Objective To understand the prevalence and influencing factors of rifampicin resistance (RR) in high-risk group of drug-resistant tuberculosis (TB) in Fujian Province and to provide references for the development of appropriate TB control strategies. Methods The information of 650 high-risk group of drug resistant TB registered in Fujian in 2018 was collected from the TB management information system of the Chinese Center for Disease Control and Prevention, including rifampicin resistance, age, gender, ethnicity, occupation, household registration, and registration classification. The prevalence of rifampicin resistance in high-risk group of drug-resistant TB was analyzed, and the influencing factors of RR in high-risk group were analyzed by univariate and multivariate logistic regression. Results Among 650 high-risk group of drug resistant TB, there were 143 cases of RR-TB, with a drug resistance rate of 22.0%. Univariate analysis showed that the RR rates of the high-risk groups with aged ≥65, male, local resident, occupation as migrant worker and registration classification as other were significantly lower than those with aged <25 (12.2% (22/180) <46.2% (12/26), χ ²=21.57, P<0.05), female (20.1% (109/541) <31.2% (34/109), χ ²=6.45, P<0.05), foreign household registration (17.8% (81/455) <31.8% (62/195), χ ²=15.58, P<0.05), occupation as housekeeping/housework/unemployed workers (18.4% (78/425) <33.6% (42/125), χ ²=13.15, P<0.05) and registration classification as retreatment failure/chronic patients (6.2% (1/16) <77.8% (7/9), χ ²=54.80, P<0.05), respectively. Multivariate logistic regression analysis showed that the risk of RR in the high-risk group with aged 25-34 and ≥65 (referenced as aged <25, OR (95%CI) were 0.32 (0.11-0.95), 0.24 (0.09-0.65)) was lower, while the risks of RR in the high-risk group with foreign household registration (referenced as local resident, OR (95%CI)=1.87 (1.19-2.93)), occupation as housekeeping/housework/unemployed workers (referenced as migrant worker, OR (95%CI)=2.01 (1.21-3.34)), and registration classification’s relapse, initial treatment failure and retreatment failure/chronic patients (referenced as other, OR (95%CI) were 10.90 (1.34-88.68), 23.69 (2.67-209.87) and 133.89 (9.50-1887.37)) were higher. Conclusion The RR rate in high-risk group of drug-resistant TB was high in Fujian. Aged <25, foreign household registration, occupation as housekeeping/housework/unemployed workers, and registration classification as relapse, initial treatment failure and retreatment failure/chronic patients were risk factors of RR in high-risk group of drug resistant TB.

Key words: Tuberculosis,pulmonary, Drug tolerance, Rifampin, Factor analysis,statistical