Risk factors of respiratory failure in type 2 diabetes mellitus patients complicated with pulmonary tuberculosis

doi:10.3969/j.issn.1000-6621.2017.12.007

Abstract

Abstract: Objective To analyze the risk factors of respiratory failure in patients with type 2 diabetes mellitus complicated with pulmonary tuberculosis, so as to provide reference for clinical treatment. Methods A total of 200 cases of pulmonary tuberculosis cases in Beijing Chest Hospital from January 2012 to December 2015 were retrospectively investigated and divided into two groups. Group A: 100 cases of type 2 diabetes mellitus patients complicated with pulmonary tuberculosis, with respiratory failure; group B: 100 cases of type 2 diabetes mellitus patients complicated with pulmonary tuberculosis, without respiratory failure. The clinical data of all patients was collected. Logistic regression analysis was used to screen risk factors. Results The clinical data of group A and group B was analyzed by single factor analysis. Significant statistical difference was found in age (χ²=18.588,P=0.000),number of affected lung fields (χ²=11.808,P=0.001),tuberculous cavity (χ²=16.330,P=0.000), hemoptysis (χ²=8.753,P=0.003), glucocorticoids (χ²=10.485,P=0.001), long-term use of antibiotics (χ²=4.750,P=0.029),tuberculosis course (χ²=9.469,P=0.009), ketoacidosis (χ²=8.414,P=0.004), and body mass index (χ²=14.474,P=0.001). Multivariable analysis of these factors further revealed that age (Wald χ²=15.527,P=0.000,OR=4.055 (95%CI:2.021-8.136)), number of affected lung fields (Wald χ²=11.938,P=0.001,OR=3.689 (95%CI:1.759-7.735)), tuberculous cavity (Wald χ²=4.844,P=0.028,OR=0.463 (95%CI:0.233-0.919)), glucocorticoids (Wald χ²=7.374,P=0.007,OR=4.765 (95%CI:1.544-14.707)),and ketoacidosis (Wald χ²=6.077,P=0.014,OR=4.859 (95%CI:1.383-17.079)), the Results had a significant statistical difference. Conclusion The results indicated that age, number of affected lung fields, tuberculous cavity, glucocorticoids application and ketoacidosis were important risk factors that led to respiratory failure in type 2 diabetes mellitus patients complicated with pulmonary tuberculosis.

Key words: Diabetes mellitus, type 2, Tuberculosis, pulmonary, Comorbidity, Respiratory insufficiency, Risk factors

WANG Xiao-wei, LUO Bao-jian, ZHANG Nan, LIU Qiu-yue, KANG Wan-li, LI Qi, CHEN Xiao-you. Risk factors of respiratory failure in type 2 diabetes mellitus patients complicated with pulmonary tuberculosis[J]. Chinese Journal of Antituberculosis, 2017, 39(12): 1286-1290. doi: 10.3969/j.issn.1000-6621.2017.12.007

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