Abstract: Objective  To discuss the method of drug use verification to evaluate the rational use of drug indirectly.  Methods  The typical survey methods were adopted and six counties were selected from Henan, Chongqing and Jilin. The information of TB case detection and treatment outcome was collected from national control quarterly report. And the information related to in- and out- store, damage or expired, out of stock was collected from account book and medical record. Out of stock rate, damage/expired rate, correct prescription rate and drug use verification difference degree were calculated according to the definitions. Totally 2122 new smear positive TB, 202 retreatment smear positive TB, and 1596 smear negative TB were involved from 2007.1－12.  The smear negative conversion rates at the end of two months’ treatment was 6.03% (128/2122) for new smear positive cases and 7.92% (16/202) for retreatment smear positive cases. Results  Out of stock rate was 1.78% (234/(36×365)) and damage/expired rate was 0.57% (2159/(125 544+250 440)). 1200 TB cases, selected by cluster sampling method, were all given the correct prescriptions in accordance with “Guidelines for Implementing the National Tuberculosis Control Program in China”. The drug use verification difference degree of HRZE was －41.93%((84 378－119 760)/84 378), with the maximum－12.1% ((13 140－14 730)/13 140) and the minimum －86.36% ((10 673－19 890)/10 673)), there were 3 counties below －25%. The difference degree of HR was －28.60%((173 475－223 080)/173 475), with the maximum－14.05% ((34 470－39 600)/34 470) and the minimum －114.51%((17 761－38 100)/17 761)), there were 2 counties below －25%. The difference degree of HRE was 31.22% ((26 434－18 180)/26 434), with the maximum 90.91% ((3960－360)/3960) and the minimum 3.52% ((2985－2880)/2985)), there were 3 counties above 25%.  Conclusion  As it’s possible that evaluating the rational drug use roughly through comparing the difference between theoretical and actual consumptions, we suggest implement drug use verification every six months or one year.

Key words: Tuberculosis, pulmonary/drug therapy, Antitubercular agents, Drug utilization, Treatment outcome