Abstract: Objective To analyze correlative factors of tuberculous destroyed lung in order to reduce occurrence of the disease.  Methods The data from 100 pulmonary tuberculosis patients with destroyed lung and 100 pulmonary tuberculosis patients without destroyed lung, who were admitted from May, 2005 to May, 2010，were investigated. Several factors including demographic data, duration of the disease, regular therapy, drug resistance, lung infection, the number of lesions, complications, hemoptysis, empyema, respiratory failure were analyzed. Results By using single factor analysis, several factors had a significant difference between two groups, including duration of the disease（χ²=84.040，P<0.001）, drug resistance(χ²=53.107,P<0.001), respiratory failure(χ²=11.753, P=0.001), concentration of hemoglobin(χ²=12.106, P=0.001), lung infection(χ²=8.036,P=0.005)、hemoptysis(χ²=11.293, P=0.001), positive sputum AFB (χ²=8.413, P=0.035), empyema(χ²=13.211,P<0.001) and the number of lesions(χ²=22.917,P<0.001). In addition, factors such as regular therapy(χ²=25.149,P<0.001), complicated with COPD(χ²=5.647, P=0.017) and concentration of albumin(χ²=6.650,P=0.010) showed significant difference between two groups. By using multivariate analysis, factors such as duration of disease［Wald χ²=24.47, P<0.01, OR=3.81(2.24-6.64)］, drug resistance［Wald χ²=20.09, P<0.01, OR=27.11 (6.40-114.79)］, complications ［Wald χ²=9.76,P<0.01, OR=4.88 (1.81-13.20)］, concentration of hemoglobin［Wald χ²=3.95,P=0.050, OR=0.38 (0.14-0.99)］, positive sputum AFB ［Wald χ²=4.68, P=0.030, OR=0.61(0.39-0.95)］ and the number of lesions ［Wald χ²=5.08, P=0.020,OR=26.53 (1.54-458.52)］were risk factors for the occurrence of destroyed lung. Conclusion Various factors contribute to the occurrence of tuberculous destroyed lung. Early and comprehensive therapy can reduce the occurrence of tuberculous destroyed lung.

Key words: Tuberculosis,pulmonary/complications, Lung diseases, Risk factors