Chinese Journal of Antituberculosis ›› 2020, Vol. 42 ›› Issue (12): 1299-1304.doi: 10.3969/j.issn.1000-6621.2020.12.009
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MA Jin-bao, MA Ting-ting, REN Fei, YANG Han(), TAN Gan-wen
Received:
2020-04-16
Online:
2020-12-10
Published:
2020-12-24
Contact:
YANG Han
E-mail:xajhyanghan@163.com
MA Jin-bao, MA Ting-ting, REN Fei, YANG Han, TAN Gan-wen. Analysis on risk factors associated with false negative results of interferon-gamma release assay in active tuberculosis[J]. Chinese Journal of Antituberculosis, 2020, 42(12): 1299-1304. doi: 10.3969/j.issn.1000-6621.2020.12.009
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因素 | IGRA阳性组 (106例) | IGRA假阴性组 (90例) | 统计检验值 | P值 | |||
---|---|---|---|---|---|---|---|
性别[例(构成比,%)] | χ2=3.133 | 0.077 | |||||
男 | 73(68.9) | 72(80.0) | |||||
女 | 33(31.1) | 18(20.0) | |||||
年龄[例(构成比,%)] | χ2=2.794 | 0.247 | |||||
17~岁 | 60(56.6) | 42(46.7) | |||||
40~岁 | 32(30.2) | 29(32.2) | |||||
≥60岁 | 14(13.2) | 19(21.1) | |||||
卡介苗接种史[例(构成比,%)] | χ2=1.371 | 0.242 | |||||
是 | 71(67.0) | 53(58.9) | |||||
否 | 35(33.0) | 37(41.1) | |||||
结核病患者类型[例(构成比,%)] | χ2=0.117 | 0.732 | |||||
初治 | 80(75.5) | 66(73.3) | |||||
复治 | 26(24.5) | 24(26.7) | |||||
并发糖尿病[例(构成比,%)] | χ2=0.014 | 0.906 | |||||
是 | 17(16.0) | 15(16.7) | |||||
否 | 89(84.0) | 75(83.3) | |||||
结核病程[例(构成比,%)] | χ2=0.203 | 0.652 | |||||
<8周 | 65(61.3) | 58(64.4) | |||||
≥8周 | 41(38.7) | 32(35.6) | |||||
痰菌[例(构成比,%)] | χ2=3.847 | 0.278 | |||||
+ | 61(57.5) | 59(65.6) | |||||
++ | 23(21.7) | 12(13.3) | |||||
+++ | 11(10.4) | 6(6.7) | |||||
++++ | 11(10.4) | 13(14.4) | |||||
对一线抗结核药品耐药[例(构成比,%)] | χ2=0.019 | 0.889 | |||||
是 | 32(30.2) | 28(31.1) | |||||
否 | 74(69.8) | 62(68.9) | |||||
BMI[M(Q1,Q3)] | 19.8(17.6,22.3) | 19.0(16.6,20.8) | Z=-2.423 | 0.015 | |||
发热[例(发生率,%)] | 35(33.0) | 41(45.6) | χ2=3.222 | 0.073 | |||
咳嗽[例(发生率,%)] | 90(84.9) | 79(87.8) | χ2=0.338 | 0.561 | |||
咳痰[例(发生率,%)] | 85(80.2) | 74(82.2) | χ2=0.131 | 0.717 | |||
体质量减轻[例(发生率,%)] | 30(28.3) | 37(41.1) | χ2=3.550 | 0.060 | |||
白细胞计数[×109个/L,M(Q1,Q3)] | 6.3(5.0,7.5) | 7.4(5.8,9.2) | Z=-3.464 | 0.001 | |||
中性粒细胞百分比( | 0.71±0.09 | 0.75±0.09 | t=-2.802 | 0.006 | |||
淋巴细胞百分比[M(Q1,Q3)] | 0.21(0.15,0.26) | 0.16(0.11,0.22) | Z=-3.528 | 0.000 | |||
血红蛋白(g/L, | 122.7±19.7 | 113.8±21.7 | t=2.986 | 0.003 | |||
血小板计数[×109个/L,M(Q1,Q3)] | 258(191,320) | 285(193,399) | Z=-2.095 | 0.036 | |||
血清总蛋白[g/L,M(Q1,Q3)] | 67.1(62.2,70.6) | 67.2(62.3,71.4) | Z=-0.087 | 0.931 | |||
血清白蛋白[g/L,M(Q1,Q3)] | 38.9(35.2,41.7) | 37.1(31.9,39.7) | Z=-2.747 | 0.006 | |||
血腺苷脱氨酶 [U/L,M(Q1,Q3)] | 12.0(9.8,16.0) | 13.0(10.0,18.0) | Z=-1.520 | 0.129 | |||
血红细胞沉降率[mm/1h,M(Q1,Q3)] | 34.5(16.0,58.0) | 53.0(31.8,84.3) | Z=-3.492 | 0.000 | |||
C反应蛋白[mg/L,M(Q1,Q3)] | 30.3(8.3,68.9) | 60.3(29.9,103.0) | Z=-3.899 | 0.000 | |||
总T淋巴细胞计数[个/μl,M(Q1,Q3)] | 918(655,1297) | 784(590,1073) | Z=-1.951 | 0.051 | |||
CD4+T淋巴细胞计数[个/μl,M(Q1,Q3)] | 553(371,737) | 432(320,645) | Z=-2.080 | 0.038 | |||
CD8+T淋巴细胞计数[个/μl,M(Q1,Q3)] | 345(225,503) | 317(219,485) | Z=-0.804 | 0.422 | |||
CD4+/CD8+比值[M(Q1,Q3)] | 1.5(1.1,1.9) | 1.4(1.0,1.8) | Z=-1.101 | 0.271 | |||
病灶累及肺野数[例(构成比,%)] | χ2=2.168 | 0.141 | |||||
<4个肺野 | 45(42.5) | 29(32.2) | |||||
≥4个肺野 | 61(57.5) | 61(67.8) | |||||
肺部空洞数[例(构成比,%)] | χ2=0.636 | 0.425 | |||||
<2个空洞 | 46(43.4) | 34(37.8) | |||||
≥2个空洞 | 60(56.6) | 56(62.2) |
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