Chinese Journal of Antituberculosis ›› 2019, Vol. 41 ›› Issue (1): 18-23.doi: 10.3969/j.issn.1000-6621.2019.01.006
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Gui-hui WU1(),Tao HUANG1,Yao CHENG1,Xiao-qiu HUANG2,Xiao-yan FU1,Yao MA1,Peng LI1,Wei HE1
Received:
2018-11-08
Online:
2019-01-10
Published:
2019-01-09
Gui-hui WU,Tao HUANG,Yao CHENG,Xiao-qiu HUANG,Xiao-yan FU,Yao MA,Peng LI,Wei HE. Analysis on clinical characteristics and prognostic of human immunodeficiency virus infected patients with tuberculous meningitis[J]. Chinese Journal of Antituberculosis, 2019, 41(1): 18-23. doi: 10.3969/j.issn.1000-6621.2019.01.006
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临床特征 | 观察组(52例) | 对照组(96例) | 统计检验值 | P值 |
---|---|---|---|---|
发热[例,发生率(%)] | 44(84.6) | 89(92.7) | χ2=2.43 | 0.119 |
头痛[例,发生率(%)] | 38(73.1) | 82(85.4) | χ2=3.35 | 0.067 |
恶心、呕吐[例,发生率(%)] | 29(55.8) | 69(71.9) | χ2=3.91 | 0.048 |
意识改变[例,发生率(%)] | 11(21.2) | 26(27.1) | χ2=0.63 | 0.426 |
脑膜刺激征[例,发生率(%)] | 19(36.5) | 45(46.9) | χ2=1.47 | 0.226 |
肌力、肌张力改变[例,发生率(%)] | 10(19.2) | 19(19.8) | χ2=0.07 | 0.935 |
营养不良[例,发生率(%)] | 41(78.8) | 38(39.6) | χ2=20.89 | 0.000 |
贫血[例,发生率(%)] | 27(51.9) | 29(30.2) | χ2=6.76 | 0.000 |
CD4+T淋巴细胞计数[个/μl,M(Q1,Q3)] | 41.0(17.0,75.0) | 204.0(100.5,327.0) | Z=4.95 | 0.000 |
并发血行播散性肺结核[例,发生率(%)] | 17(32.7) | 59(61.5) | χ2=11.17 | 0.000 |
并发其他肺外结核[例,发生率(%)] | 38(73.1) | 29(30.2) | χ2=8.27 | 0.000 |
发病至入院时间(d, | 18.0±10.4 | 27.1±11.6 | t=4.87 | 0.000 |
检查指标 | 观察组(52例) | 对照组(96例) | 统计检验值 | P值 |
---|---|---|---|---|
脑脊液压力[mm H2O,M(Q1,Q3)] | 185.0(141.0,225.0) | 284.0(197.5,315.0) | Z=3.63 | 0.000 |
白细胞总数[×106/L,M(Q1,Q3)] | 30.0(4.0,175.0) | 360.0(280.0,415.0) | Z=4.79 | 0.000 |
蛋白含量[mg/L,M(Q1,Q3)] | 1141.2(762.8,1548.6) | 1660.0(1270.0,1900.0) | Z=2.57 | 0.010 |
葡萄糖含量[mmol/L,M(Q1,Q3)] | 2.3(1.7,2.7) | 1.4(1.2,1.8) | Z=4.17 | 0.000 |
氯化物含量[mmol/L,M(Q1,Q3)] | 117.0(111.1,121.9) | 105.1(102.6,112.4) | Z=4.19 | 0.000 |
分枝杆菌培养阳性[例,阳性率(%)] | 9(17.3) | 21(21.9) | χ2=0.44 | 0.509 |
GeneXpert MTB/RIF检测阳性[例,阳性率(%)] | 13(25.0) | 33(34.4) | χ2=1.38 | 0.239 |
临床特征 | 好转(20例) | 恶化和死亡(32例) | 统计检验值 | P值 |
---|---|---|---|---|
年龄(岁, | 34.4±10.3 | 36.9±14.8 | t=-5.56 | 0.597 |
发热[例,发生率(%)] | 17(85.0) | 27(84.4) | χ2=0.00 | 0.952 |
头痛[例,发生率(%)] | 16(80.0) | 22(68.8) | χ2=0.79 | 0.374 |
意识改变[例,发生率(%)] | 3(15.0) | 8(25.0) | χ2=0.74 | 0.390 |
体质量指数( | 21.2±2.7 | 18.4±2.0 | t=3.42 | 0.008 |
体质量指数<18.0[例,发生率(%)] | 5(25.0) | 18(56.3) | χ2=4.87 | 0.027 |
血红蛋白(g/L, | 108.6±22.4 | 91.8±15.4 | t=2.55 | 0.018 |
血红蛋白<60g/L[例,发生率(%)] | 3(15.0) | 14(43.8) | χ2=4.62 | 0.032 |
CD4+T淋巴细胞计数[个/μl,M(Q1,Q3)] | 53.0(34.0,78.0) | 28.0(11.5,55.5) | Z=2.34 | 0.019 |
CD4+T淋巴细胞计数<50个/μl[例,发生率(%)] | 4(20.0) | 17(53.1) | χ2=5.61 | 0.018 |
规范行抗病毒治疗[例,发生率(%)] | 15(75.0) | 13(40.6) | χ2=5.85 | 0.016 |
规范行抗结核治疗[例,发生率(%)] | 12(60.0) | 9(28.1) | χ2=5.19 | 0.023 |
影响因素 | β值 | s | Wald χ2值 | P值 | OR(95%CI)值 |
---|---|---|---|---|---|
常量 | -0.82 | 0.49 | 2.68 | 0.102 | |
体质量指数<18.0 | 1.01 | 0.68 | 2.19 | 0.138 | 2.74(0.72~10.35) |
血红蛋白<60g/L | 1.12 | 0.78 | 2.04 | 0.153 | 3.05(0.66~14.10) |
CD4+T淋巴细胞计数<50个/μl | 1.43 | 0.66 | 4.69 | 0.030 | 4.21(1.15~15.45) |
规范行抗病毒治疗 | 2.03 | 0.65 | 9.85 | 0.002 | 0.13(0.04~0.47) |
规范行抗结核治疗 | 1.27 | 0.62 | 4.32 | 0.040 | 0.28(0.05~0.94) |
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