Abstract: Objective To understand the epidemiological features of tuberculosis in Guangdong province in order to evaluate the implementation of tuberculosis control strategy from 2001 to 2010. Methods Stratified cluster random sampling Methods were used for this survey. Patients were diagnosed through inquiry of suspected symptoms, chest radiograph, sputum smear test,Mycobacterium tuberculosisculture and drug resistant test. The social-economic survey and awareness survey were conducted through questionnaires. Results 1) The prevalence of active pulmonary tuberculosis was 229.97/100 000 among which smear positive tuberculosis (39.75/100 000) and bacterial positive tuberculosis(62.46/100 000). 2) The prevalence status was higher in male (χ²=59.1,P＜0.01）, elderly population (χ²=89.3,P＜0.01）, rural areas (χ²=19.0,P＜0.01）,andless developed areas(χ²=28.7,P＜0.01）, the total drug resistant rate was 22.0%. 3) Compared with the survey data of 2000 and 1990, the prevalence of active tuberculosis decreased 36.8% and 60.4% respectively, the smear positive tuberculosis declined 66.7% and 71.7% respectively. Conclusion 1) Remarkable progress in TB control work were made over the past decade in Guangdong province. The epidemic continues to show a downward trend, and the active tuberculosis decreased 60.4% in comparison with the baseline of 1990, the annual descending rate of smear positive PTB was 10.4%. Guangdong finished the TB control target set by WHO ahead of schedule, and the annual descending rate closed to the world level. 2) Guangdong province still have high tuberculosis burden with the challenge from drug resistant tuberculosis. National tuberculosis control strategy should be implemented thoroughly with more support for the less developed regions.

Key words: tuberculosis,pulmonary lepidemiology, epidemiologic studies, sampling studies, Guangdong province