Abstract: Objective To analyze the factors affecting multi-drug resistance tuberculosis (MDR-TB) development among recruit patients of drug resistant (DR) surveillance programme in Heilongjiang.  Methods Questionnaire survey was conducted on all MDR-TB cases of DR surveillance programme, and their information recorded was collected and analyzed.  Results The proportion of MDR-TB patients among retreatment cases was higher, the main factors affecting MDR-TB development were residence place, number of days of prior treatment and times of prior treatment. Conclusion The longer prior irregular treatment and the more prior irregular treatment received, the more likely MDR-TB occur. Implementation of high quality DOTS can reduce MDR-TB ultimately.

Key words: tuberculosis, pulmonary, multidrug-resistant, drug-resistance, multiple, bacterial