Abstract: Objective  To investigate the correlation between the treatment outcome of endobronchial tuberculosis (EBTB) and the levels of interferon-γ (IFN-γ) and transforming growth factor-β (TGF-β) in the serum and bronchoalveolar lavage fluid(BALF). Methods  The levels of IFN-γand TGF-βwere measured by the ELISA method in the serum and BALF among 78 patients with EBTB before and after treatment and 50 healthy control. 78 patients with EBTB and fifty healthy controls were enrolled. The EBTB patients were divided into Group 1 in which 〖JP2〗patients who exhibited bronchial stenosis after treatment and Group 2 who had no bronchial stenosis. Results (1) IFN-γ  and TGF-β levels of the BALF in patients with EBTB were higher than those in the healthy controls. (2) Of the 78 patients with EBTB after treatment, 27 cases exhibited bronchial fibrostenosis and the other 51 cases had recovered without sequelae. The levels of IFN-γ ［（2152±1594.33）pg/ml］and TGF-β ［（1219.54±439.27 ）pg/ml］in the BALF  of the EBTB patients with bronchial fibrostenosis were higher than the patients without bronchial fibrostenosis in which IFN-γ was［(1006.3±752.57) pg/ml ］and TGF-β ［(779.24±395.91) pg/ml］(U=4.3553, 3.5315，respectively, all P＜0.01）. The level of TGF-β ［(783.21±478.67) pg/ml］in the serum from the EBTB patients with bronchial fibrostenosis was lower than that of TGF-β ［(1258.6±573.29) pg/ml］in the serum from EBTB patients without bronchial fibrostenosis (U=3.8905，P＜0.01）.  Conclusion   (1)Elevated IFN-γ and TGF-β levels in the BALF of the EBTB patients may be related to the pathogenesis of EBTB. (2) Low level of TGF-β in serum and high levels of IFN-γ and TGF-β in the BALF are correlated witn bronchial fibrostenosis in EBTB after treatment.

Key words: Tuberculosis, bronchi/therapy, Constriction,pathologic, Interferon type Ⅱ, Transforming growth factor beta