Abstract: Objective To explore the change and value of sIL-2R, TNF-α, IFN-γ and IL-6 in the serum samples of patients with pulmonary tuberculosis.  Method The levels of sIL-2R, TNF-α, IFN-γ and IL-6 were measured using the sandwich ABC-ELISA method in 214 patients with pulmonary tuberculosis.   Result The levels of sIL-2R in sera in each group were higher than normal, and increased with lesion scope enlarged, in which the levels of sIL-2R in 3-4 lung field group and  5-6  lung field group were significantly higher than those in 1-2 lung field group(P<0.01). The levels of sIL-2R in the smear-positive group were significantly higher than those in smear-negative group(P<0.01).The levels of TNF-α in sera in 1-2 lung field group and 3-4 lung field group were higher than normal, and decreased with lesion scope enlarged. The levels of TNF-α in 1-2 lung field group were higher than those in 5-6 lung field group, which were normal (P<0.01). The levels of TNF-α in non-cavity group were higher than those in cavity group(P<0.05).The levels of INF-γ in sera in each group were higher than normal, and in 5-6 lung field group were higher than those in  3-4  lung field group(P<0.05). The levels of INF-γ in the smear-positive group were higher than those in smear-negative group (P<0.05).   Conclusion The levels of sIL-2R, TNF-α, IFN-γ and IL-6 in the serum samples of different patients with pulmonary tuberculosis were different．These cytokines may be play roles in the pathogenesis of tuberculosis.

Key words: tuberculosis, pulmonary/blood, receptors,interleukin-2, tumor necrosis factor-alpha, interferon typy Ⅱ, interleukin-6