Abstract: Objective To analyze and evaluate the trend of drugs resistance of Mycobacterium tuberculosis, and to provide evidence for tuberculosis (TB) control. MethodsThe strains of in-patients and out-patients during the years of 2001—2005 were consecutively collected, and drug susceptibility test (DST) was conducted on the strains. ResultsThe drug resistance rates were 26.2%、29.1%、27.2%、30.9% and 25.6% respectively; the rate of initial resistance were 14.9%、17.9%、12.8%、9.3% and 9.5% respectively; acquired resistance rate were 67.6%、69.7%、57.4%、61.9% and 68.3%. The single-drug resistant rate to INH, RFP and SM were higher than that to other drugs, The multi-drug resistant rate to SH, SR, HR, SHR, HRE, SHRE combination were higher. ConclusionThe total drug resistant rate of TB in Quanzhou is very high and the situation is quite serious, the keys of drug resistance control are early detection and treatment to completely cure infectious TB with DOTS strategy, and improve the evaluation of drug resistance monitoring.

Key words: tuberculosis, prevention, control, drug resistance