Abstract: Objective To study the risk factors,clinical characteristics and Methods of diagnosis and treatment of secondary fungal infection in MDR-PTB cases in order to improve the recognition and treatment of the coexistence of two diseases. Methods Fifty-one cases of MDR-PTB compli-cated with fungi infection in our department from 2002 were retrospectively analyzed. Results Fifty-one cases had susceptible factors of fungus infection. The major clinical features were as follows： they had a long history of tuberculosis； usually occurred in older patients；they had extensive range of lesions and many cavities in lungs； Their diagnosis depended on the examination of pathogenic organisms, type of fungi in 51 cases was Candida Albicans. Conclusion It is common that fungal infection occurred in MDR-PTB cases. Improving the recognition on the two diseases will be contribute to MDR-PTB control and reduce death rate.

Key words: tuberculosis, pulmonary/complication, tuberculosis,multidrug-resistant/complication, lung disease, fungus