Abstract: Objective To study the antituberculous activities of Pittosporum brevicalyx (Oliv.) Gagnep. Methods The MIC of Pittosporum brevicalyx (Oliv.)Gagnep and the sera containing Pittosporum brevicalyx(Oliv.)Gagnep were determined. The antituberculous effect of Pittosporum brevicalyx (Oliv.)Gagnep was evaluated in mouse model. Results The MIC of Pittosporum brevicalyx(Oliv.)Gagnep and the sera containing Pittosporum brevicalyx (Oliv.)Gagnep were 0.25～0.5mg/ml and 80μg/ml, repectively. Pittosporum brevicalyx (Oliv.) Gagnep could prolong the survival time and improve livability in the tuberculous mouse model. Conclusion Pittosporum brevicalyx(Oliv.)Gagnep exhibited antituberculous activities in vitro and in vivo, and might be developed as a new crude antituberculosis drug.

Key words: Pittosporum brevicalyx(Oliv. )Gagnep, M. tuberculosis