Abstract: Objective To observe and analyse the therapeutic effects and safety of different regiments to new pulmonary tuberculosis patients with smear-positive.To evaluate the validity and security of levofloxacin in elderly patients. Methods One hundred and three elderly new pulmonary tuberculosis patients with smearpositive were allocated into the treatment group（Ⅰ group,2HL₂EV/10HL₂E)）、control group（Ⅱ group,2HL₂EZ/10 HL₂E）and individualized group（Ⅲ group,18HL2E or 18HVE or 18HL2V）.The sputum conversion rates,chest X-ray improvement rates, one-year relapse rates and the side-effects of anti-tuberculosis drugs were observed. Result The sputum conversion rates at the end of therapeutic course in group Ⅰ,Ⅱ,Ⅲ were 97.4%,93.1%,95.0%,respectively（P>0.05）.The improving rates of chest X-ray were 87.2%,89.7%,80.0%,respectively（P>0.05）.The cavity closure rate was 35.3% in group Ⅰ,33.3% in group Ⅱ and 31.3% in group Ⅲ,（P>0.05）.One-year bacteriological relapse rate were 7.9%, 3.7%, 5.3%, respectively（P>0.05）.The side-effect rate was 24.5% in group I and 54.8% in group Ⅱ（P<0.01）. Conclusion The treatment effects of regimen including cravit was the same as that of regiment including pyrazimide.The cravit was safe to elderly patients.The side-effect rate caused by pyrazinamide was significant higher than that of cravit.The individualized regiment also has satisfied theraputic effect.

Key words: Pulmonary tuberculosis/Drug therapy, Aged