Abstract:

Objective To investigate the nutritional status of elderly tuberculosis inpatients in Shanghai and its impact on clinical treatment and provide a reference for early nutrition intervention for elderly tuberculosis inpatients. Methods Of the 1100 elderly tuberculosis inpatients admitted in Shanghai Pulmonary Hospital Affiliated of Tongji University over 24 hours from August 1st, 2018 to August 1st, 2019 were, 900 patients without serious diabetes, serious hypertension, liver and kidney dysfunction, or unconsciousness were collected, and their BMI were recorded. Clinical data, including gender, age, diagnosis, complication, times of treatments, date of discharge and admission, NRS 2002 score and nutrition relative indicators (Hb, TP, ALB, PAB, RBP, PNI, and NLR), were compared to analyze the risk factors of elderly tuberculosis inpatients. The 900 elderly tuberculosis patients were divided into nutritional risk group (n=443 (49.22%), NRS 2002 score ≥3) and non-nutritional risk group (n=457 (50.78%), NRS 2002 score<3). Results The constituent ratio of nutritional risks in the nutritional risk group with patients aged 75- and 80-90 years old, BMI<18.5,2 or more times of treatments,tuberculous pleurisy were significantly higher than the non-nutritional risk group (18.28% (81/443) and 18.51% (82/443) vs.9.19% (42/457) and 8.75% (40/457), (40.41% (179/443) vs. 0.00% (0/457),25.51% (113/443) vs. 17.51% (80/457),21.67% (96/443) vs. 13.13% (60/457);χ²=51.350,299.500, 8.818, 16.280;P=0.000,0.000,0.012,0.000). The TP, ALB, PAB, Hb, RBP, PNI in nutritional risk group were lower than those in non-nutritional risk group ((64.88±0.34) g/L vs. (67.30±0.28) g/L, (34.15±0.23) g/L vs. (38.18±0.16) g/L, (138.60±3.26) g/L vs. (194.10±3.22) g/L, (113.60±0.84) g/L vs. (126.70±0.79) g/L, (26.32±0.50) g/L vs. (34.32±0.22) g/L, (39.61±0.35) vs. (45.51±0.26); F=19.496, 79.334, 34.030, 22.808, 21.326, 72.464, respectively; all P=0.000). However, the NLR and duration of inhospital in nutritional risk group were significantly higher than those in non-nutritional risk group ((5.44±0.32) vs. (3.29±0.14), F=6.335, P=0.012; (6.61±0.17) d vs. (5.53±0.13) d, F=5.994,P=0.015). Conclusion Elderly tuberculosis patients have high incidence of nutritional risk and the incidence increase with age, times of treatment, decrease with BMI. The TP, ALB, PAB, Hb, RBP and PNI in nutritional risk group were significantly lower than those in non-nutritional risk group, which seriously affects the clinical treatment and leads to longer hospital stays directly.

Key words: Tuberculosis, Aged, Nutrition assessment, Nutrition surveys, Factor analysis, statistical