Abstract: Objective To determine the infection status and clinical significance of transfusion transmitted virus(TTV) and hepatitis G virus(HGV) in the patients with tuberculosis in Baise minority nationality regions.Method Anti-TTV and anti-HGV were detected with enzyme linked immune absorption assay(ELISA) in the serums of 712 tuberculosis patients and 500 control subjects.TTV-DNA was detected with polymerase chain reaction(PCR) in the subjects which anti-TTV was positive.HGV-RNA was detected with PT-nPCR in the subjects which anti-HGV was positive.Clinical character of tuberculosis patients with positive TTV DNA or positive HGV-RNA was investigated.Results The infection rate of TTV was 16.71% in the tuberculosis patients and 5.60% in the control subjects.The infection rate of HGV was 14.61% in the tuberculosis patients and 2.60% the in control subjects.There is significant difference in two groups(P<0.01).The infection rate of TTV and HGV has a trend to rise by age in the tuberculosis patients.The rate in male group is higher than in female group(P<0.05).And the infected people have a higher rate of having blood transfusion and injection history than the uninfected people.Liver injury resulting from antitubercular drugs is more common occurred in the patients infected with TTV-DNA and HGV-RNA during tuberculosis therapy(P<0.01).Conclusion The Results of the study suggest that the infection rate of TTV and HGV is in a relatively high level in the tuberculosis patients.Immune function damage and multi-injection may contribute to it.And the infected patients are easier to suffer the liver damage during tuberculosis therapy.

Key words: Tuberculosis, Hepatitis G virus, Transfusion transmitted virus, Infection