Abstract: Objective To evaluate the assistant value of Vaccae on treatment of multi-durg resistance pulmonary tuberculosis. Method Sixty cases with multi-durg resistance pulmonary tuberculosis were divided randomly into the treatment group and the control group.The cases in 2 groups were treated by the same chemotherapy regimen with 3PaL₂AkZThV/15PaL₂ZThV.in the same time.The treatment group cases were injected vaccae （22.5μg） every 15-day in the first three month,then observe the change of the market absorption,sputum conversion,symptom improvement,immune function in the two groups after the treatment. Results There was significant difference on the rates of sputum smear negative conversion.In the two groups,they were 56.6% and 26.6% at the end of 3 months,93.3% and 73.3%at the end of 18 months respectively,there were obvious difference of CD4,CD4/CD8 focus absorption and closure rates of cavities at the end of 9 months between the treatment group and control group. Conclusion Vaccae is helpful to the immune function,sputum negative conversion and the absorption of focus,it has a adjustment treatment of multi-drug cases.

Key words: Tuberculosis, multidrug resistance/therapy