Abstract: Objective To observe the curative effect intrapleural urokinase for tuberculous pleurisy.Methods One hardred and twenty patients with tuberculous pleurisy were randomly divided into 2 groups:treatment group and control group.The patients in the treatment group were injected with urokinase 100000IU intrapleurally each time after 1,2,3 thoracocentesis,and the patients in the control group were injected with 20ml physiological saline each time.The other therapies in both groups were the same.Results The duration of pleural effusion absorption in treatment group was (20.2±3.1) days,while it was (19.6±4.2) days in control group (P＞0.05).The mean volume of fluid drained in treatment group was (3648±512)ml,while it was (2934±478)ml in control group (P＜0.01).The mean number of fluid drained in treatment group was (5.2±1.6),while it was (4.8±1.6) in control group (P＞0.05).There were two patients with pleural adhesion and loculation in treatment group,but there were 9 cases in control group (P＜0.01).After two months,the mean thickness of pleura in treatment group was (1.22±0.19)mm by B ultrasonic wave test,but it was (1.48±0.32)mm in control group (P＜ 0.01).The lung function (FEV1%) examined was (89.2±1.6%) in treatment group,while it was (82.3±2.1%) in control group (P＜0.01).FVC% was (94.3±2.2%) in treatment group,while it was 90.2±2.4% (P＜0.01) in the control group.Conclusion Intrapleural urokinase can not only reduce pleural adhesion,loculation and thickening of the pleura but also improve lung function.

Key words: Urokinase, Tuberculosis pleurisy