Abstract: Objective In order to find a good regimen to tre at tuberculosis patient,the study was carried out to treat initial smear positive TB cases with 2H₂R₂Z₂S₂(E₂)/4H₂R₂,2H₃R₃Z₃S₃(E₃)/4H₂R₂,compairedwith the result that TB cases treated with the regimen in TB contro l program in our country. Methods Twenty TB dispansaries were randomly selected as the st udy fields. Initial smear positive TB cases were chosen as study subjects and were divided into three groups(groupⅠ, groupⅡand group Ⅲ) randomly and were treated with different kinds of short course intermittent regimens of chemothera py.Results The smear negative conversion rates of the three g roups at the end of the sixth month during the treatment courses were 95.96%, 97 .98%, 97.37% respectively. There were not significant differences among them (P>0.05). Side effect rates of three groups after treatment were 22.73%, 33.88% and 40.00% respectively. The re were significant defferents between groupⅠand other two groups(P<0.01).B ut there was no significant difference between groupⅡ and group Ⅲ(P>0.05). The relapse rates of the three groups were 4.86%, 3.70% and 2.76% respectively and there were no significant differences among them(P>0.05). Average times of each cases of three groups ta king drugs in full treatment courses were 60, 70.48 and 90 times respectively. Conclusion The two experimental chemotherapy regimens have got almost the same Results with control group. The side effect rate of cases in group Ⅰ was less than th at in other two groups. The costs of the TB patients were reduced in the experim ent groups.

Key words: Tuberculosis, pulmonary/chemotherapy