Abstract:

This is a retrospective study to analyze the effect of postoperative analgesia with flurbiprofen axetil on postoperative fever in spinal tuberculosis patients.The clinical data (operation time, number of incisions, operation site, intraoperative blood transfusion, intraoperative use of glucocorticoid, the use of flurbiprofen axetil as postoperative analgesia, and fever 2 days after operation) of 255 spinal tuberculosis patients undergoing surgery in Beijing Chest Hospital from January 2017 to January 2019 were analyzed. The results showed that the fever rate was 44.7% (114/255) on the first day after operation, and 77.3% (109/141) of the patients who used flurbiprofen axetil for analgesia had no fever, which was significantly higher than that of the patients who did not use flurbiprofen axetil for analgesia (22.7% (32/141), χ²=11.970, P=0.001). The fever rate was 28.6% (73/255) on the second day after operation, and 72.5% (132/182) of the patients who used flurbiprofen axetil for analgesia had no fever, which was significantly higher than that of the patients who did not use flurbiprofen axetil for analgesia (27.5% (50/182), χ²=5.400, P=0.020). Multivariate logistic analysis showed that on the first and second day after spinal tuberculosis surgery, the risk of fever was reduced values (OR (95%CI) were 0.319 (0.178-0.570) and 0.412 (0.222-0.764), respectively). According to the results, postoperative analgesia with flurbiprofen axetil could reduce the risk of postoperative fever in patients with spinal tuberculosis.

Key words: Tuberculosis, spinal, Surgical procedures, operative, Anti-inflammatory agents, non-steroidal, Fever