Abstract:

Therapeutic drug monitoring (TDM) is a technique that determining the dose of drugs based on the concentration of drugs in blood, urine or saliva, and developing therapeutic regimens to achieve the best treatment effect, and to reduce the drug resistance and adverse reactions. TDM is an important strategy of individualized treatment, which can provide references for individualized doses. Individual differences were found in blood concentrations of tuberculosis (TB) patients, and there were also many adverse reactions.All of these always caused ineffective treatment, relapse or drug resistance. TDM has not yet been standardized and no official guidelines have been developed in anti-TB therapy. However, TDM were recently recommend in foreign guidelines for TB patients who have risk of drug exposure altered or poor prognosis. Therefore, the authors reviewed the definition and clinical significance of TDM, as well as the detection techniques and methods, and application in anti-TB therapy, in order to provide references for clinicians.

Key words: Drug monitoring, Tuberculosis, Blood concentration