Chinese Journal of Antituberculosis ›› 2021, Vol. 43 ›› Issue (3): 228-232.doi: 10.3969/j.issn.1000-6621.2021.03.007
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YANG Qing-luan*, LIU Qi-hui, LIN Miao-yao, XU Yu-zhen, LIU Xue-feng, HE Zhang-yu-fan, HUANG Xi-tian, HAO Bin, SHAO Ling-yun, ZHANG Wen-hong, RUAN Qiao-ling()
Received:
2021-01-26
Online:
2021-03-10
Published:
2021-03-03
Contact:
RUAN Qiao-ling
E-mail:qlruan07@fudan.edu.cn
YANG Qing-luan, LIU Qi-hui, LIN Miao-yao, XU Yu-zhen, LIU Xue-feng, HE Zhang-yu-fan, HUANG Xi-tian, HAO Bin, SHAO Ling-yun, ZHANG Wen-hong, RUAN Qiao-ling. A study of pharmacokinetic of rifapentine combined with isoniazid in the preventive treatment of tuberculosis in silicotic patients[J]. Chinese Journal of Antituberculosis, 2021, 43(3): 228-232. doi: 10.3969/j.issn.1000-6621.2021.03.007
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药品及其代谢产物 | AUC(0~t) (μg·h/ml) | AUC(0~∞) (μg·h/ml) | t1/2(h) | tmax(h) | Cmax (μg/ml) |
---|---|---|---|---|---|
异烟肼 | 14.1(10.3,22.2) | 14.3(10.7,22.4) | 1.6(1.3,1.8) | 2.0(2.0,4.0) | 3.7(2.4,5.5) |
乙酰异烟肼 | 7.6(6.3,8.4) | 8.0(7.2,9.2) | 6.0(5.2,7.9) | 2.0(2.0,4.5) | 6.6(5.5,9.8) |
利福喷丁 | 919.6(742.3,1113.1) | 1035.4(758.2,1191.3) | 18.3(14.5,21.6) | 8.0(7.0,12.0) | 32.2(28.6,37.7) |
25-去乙酰利福喷丁 | 660.1(517.6,739.8) | 913.4(685.7,1097.3) | 32.3(22.1,46.3) | 24.0(18.0,24.0) | 15.1(11.2,18.2) |
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