Chinese Journal of Antituberculosis ›› 2020, Vol. 42 ›› Issue (4): 398-403.doi: 10.3969/j.issn.1000-6621.2020.04.018
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XIANG Hai-bin,LIANG Qiu-zhen,LI Xin-xia,SONG Xing-hua()
Received:
2019-12-10
Online:
2020-04-10
Published:
2020-04-07
Contact:
Xing-hua SONG
E-mail:songxinghua19@163.com
XIANG Hai-bin,LIANG Qiu-zhen,LI Xin-xia,SONG Xing-hua. Advances in the application of anti-tuberculosis nanoscale drug delivery system targeting macrophages[J]. Chinese Journal of Antituberculosis, 2020, 42(4): 398-403. doi: 10.3969/j.issn.1000-6621.2020.04.018
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URL: http://www.zgflzz.cn/EN/10.3969/j.issn.1000-6621.2020.04.018
分类 | 纳米载体 | 优点 | 缺点 |
---|---|---|---|
聚合物 | 明胶、聚乳酸-羟基乙酸共聚物、聚乳酸、聚酸酐、聚丙烯酸酯、树枝状大分子 | 工艺简单;理化特性可控;生物稳定性高;多途径给药 | 体内降解速度慢;易蓄积;有机溶剂残留毒性 |
脂质体 | 长循环脂质体、糖基脂质体、pH敏感性脂质体 | 技术成熟;无有机溶剂制备;生物降解性及相容性高 | 物理稳定性差;半衰期短;药物负载能力低 |
多糖 | 藻酸盐、直链淀粉、壳聚糖、透明质酸、环糊精 | 本质为碳水化合物;毒性极低;廉价;生物相容性高;生物可降解性好 | 载药量和释放效率低 |
碳纳米 | 石墨、氧化石墨烯、碳纳米管、富勒烯和金刚石 | 载体表面可诱捕细菌且存在大量官能团;易被配体修饰 | 生物利用度低;生物稳定性差;急性炎症反应和进行性纤维化等毒性 |
金属载体 | 银纳米颗粒、镓纳米颗粒、金纳米颗粒、铁纳米颗粒 | 可干扰MTB代谢;具有抗菌活性 | 生物利用度低;时间相关的细胞毒性;重金属中毒 |
文献发 表年份 | 配体 | 纳米载体 | 药物 | 粒径(nm) | 电位(mV) | 包封率(%) | 载药率(%) | 靶向细胞 |
---|---|---|---|---|---|---|---|---|
2019 | 甘露糖 | 氧化石墨烯 | 利福平 | 50~300 | -25 | -b | -b | 恒河猴巨噬细胞[ |
2018 | 甘露糖 | 硬脂胺-脂质体 | 利福平 | 160~250 | 25.7 | 95.5 | 3.5 | 人THP1巨噬细胞系[ |
2018 | 甘露糖 | 硬脂胺-脂质体 | 异烟肼 | 452~530 | 26.9~38.6 | 34.0~50.2 | 1.6~2.3 | 人THP1巨噬细胞系[ |
2018 | β-葡聚糖 | PLGA | 利福平 | 283.1 | -28.6 | -b | 1.1 | 人THP1巨噬细胞系[ |
2017 | 聚乙二醇 | PLGA | 莫西沙星 | 112.16 | 4.76 | 76.55 | 86.75 | 巨噬细胞[ |
2017 | 甘露糖 | 脂质体 | 利福平 | 720~1380 | 44.4~63.7a | 25.5~44.3 | 6.75~14.53 | 鼠J774巨噬细胞系[ |
2016 | 甘露糖 | 硬脂胺-脂质体 | 利福布汀 | 213 | 37.6 | 90 | -b | 鼠RAW264.7细胞系[ |
2015 | 甘露糖 | 阳离子脂质 | 利福平 | 157.4 | 34.3 | 91.6 | 38.4~42.2 | 鼠肺泡NR8383细胞[ |
2015 | 霉菌酸 | PLGA | 异烟肼 | 253~929 | 23.3~21.4a | -b | -b | 鼠骨髓巨噬细胞[ |
2015 | 透明质酸 | 生育酚琥珀酸酯胶束 | 利福平 | 238~299 | 23.7~30.9a | -b | 70.01~79.09 | 鼠肺泡MH-S巨噬细胞[ |
2011 | 甘露糖 | 明胶 | 异烟肼 | 343 | 13.17 | 43.2 | -b | 鼠J774巨噬细胞系[ |
2010 | 乳糖 | PLGA | 利福平 | 184 | -3.2 | 42.2 | 78.4±1.14 | 肺泡巨噬细胞[ |
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