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Chinese Journal of Antituberculosis ›› 2019, Vol. 41 ›› Issue (11): 1223-1226.doi: 10.3969/j.issn.1000-6621.2019.11.014

• Review Articles • Previous Articles     Next Articles

Progress on the application of matrix-assisted laser desorption ionization-time of flight mass spectrometry in the field of tuberculosis research

MU Cheng(),WANG Chun-hua   

  1. Tuberculosis Reference Laboratory, Tianjin Center for Tuberculosis Control, Tianjin 300041, China
  • Received:2019-09-24 Online:2019-11-10 Published:2019-12-05

Abstract:

Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), which has the advantages of high throughput, high speed, automation, etc., has become an important tool for bio-macromolecular research. It has made remarkable progress on clinical research and has become increasingly prominent in the field of tuberculosis research. This review mainly introduced the application of MALDI-TOF MS in the identification of mycobacterium, research of drug-resistance tuberculosis, screening of tuberculosis serum markers, detection of tuberculosis susceptibility gene polymorphisms and research of anti-tuberculosis drug metabolism in order to strengthen the understanding to MALDI-TOF MS in the field of tuberculosis research.

Key words: Tuberculosis, Spectrometry, mass, matrix-assisted laser desorption-ionization, Review literature as topic