Genotypic analysis of Mycobacterium tuberculosis among prison population in Tianjin, China

doi:10.3969/j.issn.1000-6621.2019.03.022

Abstract

Abstract:

The aim of study was to evaluate the prevalence of the sublineages of Mycobacterium tuberculosis (MTB) Beijing genotype circulating strains based on the region of differences polymorphisms in the prisons in Tianjin, China. Overall 124 MTB strains, which were isolated from the sputum samples of patients with pulmonary tuberculosis in the prisons in Tianjin from Jan. 2013 to Jun. 2016, were included. Beijing genotype strains accounted for 93.5% (116/124). Among these Beijing genotype strains, 96 (82.8%) were modern Beijing strains, and 20 (17.2%) were ancient Beijing strains. Based on large fragment polymorphism analysis, the 116 Beijing genotype strains were further grouped in four sublineages. Among the 20 ancient Beijing strains, 7 (6.0%) strains were RD181(+), and 13 (11.2%) strains were RD181(-). Of the 96 modern Beijing strains, 95 belonged to RD150(+) sublineage, accounting for 81.9% of the Beijing genotype stains, and only 1 (0.9%) strain with RD150 deletion was found in this study. RD150(+) modern Beijing sublineage were predominant among the prisoners in Tianjin. Our data showed the need for continued surveillance of RD150(+) modern Beijing sublineage transmission among prison inmates in Tianjin, China.

Key words: Mycobacterium tuberculosis, Genetic testing, Genotype, Molecular epidemiology, Prisoners

Tong XIE,Chun-hua WANG,Hui ZHAO,Han-fang JU,Cheng MU,Zhi-rui WANG,Rui SUN. Genotypic analysis of Mycobacterium tuberculosis among prison population in Tianjin, China[J]. Chinese Journal of Antituberculosis, 2019, 41(3): 361-363. doi: 10.3969/j.issn.1000-6621.2019.03.022

Figures/Tables 1

References 16

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北京基因型分支	差异序列			NTF区IS6110	菌株数 (株)	构成比 (%)
北京基因型分支	RD181	RD150	RD142	NTF区IS6110	菌株数 (株)	构成比 (%)
1	+	+	+	-	7	6.0
2	-	+	+	-	13	11.2
3	-	+	+	+	95	81.9
4	-	-	+	+	1	0.9