Tuberculosis of the thymus—2 cases report and review of the literature

doi:10.3969/j.issn.1000-6621.2019.03.019

Abstract

Abstract:

In the study, we reported two cases who diagnosed as thymic tuberculosis (TB), their clinical characteristics, such as symptoms, image findings, tuberculin skin test, T-SPOT.TB, treatment and outcome, were summarized and evaluated, retrospectively. Moreover, between 1958 and 2016, patients with thymic TB (n=24) reported by others (21 studies) were also analyzed. Overall, thymic TB is extremely rare. Although routine chest CT and other image findings suggest the disease, it couldn’t confirm it. Nevertheless, bacteriological and histological examinations can make a definite diagnosis, so in order to identify the cause of mediastinal mass, these assays should be considered in practice. In addition, for management of suspected thymic TB patients, diagnostic treatment should be prescribed timely, and the lesions should be treated surgically when indications arise. Meanwhile, it is recommended to follow standard anti-TB treatment for a better outcome.

Key words: Tuberculosis, Thymus gland, Thymectomy, Thymoma, Comorbidity, Consensus development conferences as topic

Da-wei LIU,Jian-kun ZHU,Feng JIN,Cheng WANG,Gao-feng QIAO,Yun-zeng ZHANG,Bin ZHAO. Tuberculosis of the thymus—2 cases report and review of the literature[J]. Chinese Journal of Antituberculosis, 2019, 41(3): 348-352. doi: 10.3969/j.issn.1000-6621.2019.03.019

Figures/Tables 3

References 23

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文献序号	性别	年龄 (岁)	报道时间(年)	临床表现	并发疾病	检查项目	抗结核治疗方案
1	女	20	1992	咳嗽、呼吸困难4个月	肺结核	胸部CT检查(+);术后病理(+)	H-R-E-Z
3	女	28	1998	胸闷1年	胸腺瘤、纵隔淋巴结结核	胸部CT检查(+);术后病理(+)	未提及
4	男	68	2004	胸闷、憋气、胸痛6个月	胸腺瘤、纵隔淋巴结结核	胸部CT检查(+);术后病理(+)	9H-R-Sm
5	男	15	2011	胸痛、胸闷	无	结核菌素试验阴性,胸部CT检查(+);术后病理(+)	抗结核药物治疗6个月,随访12个月后无复发
6	男	46	2008	发热、咳嗽5个月	纵隔淋巴结结核	结核菌素试验弱阳性;胸部CT检查(+);术后病理(+)	抗结核药物治疗6个月,复查无复发
7	男男女	15 62 53	2014	进行性胸痛、呼吸困难	无	胸部CT检查(+);术后病理(+)	未提及
16	女	62	2005	轻度呼吸困难、前胸疼痛	乳腺癌	胸部CT检查(+);术后病理(+)	手术前后均未治疗
17	男	18	2007	进行性呼吸困难、胸痛	肺结核	胸部CT检查(+);术后病理(+)	未提及
18	男女	74 56	2007	因心脏病查体发现干咳	风湿性关节炎;糖尿病	胸部CT检查(+);术后病理(+)	具体未提及
21	男	0.5	2014	进行性呼吸困难	体质量偏低	结核菌素试验强阳性;胸部CT检查(+);术后病理(+)	2H-R-Z-Sm/T-H-R
22	女	12	2016	右颈部肿物伴咳嗽1个月	颈部淋巴结结核	胸部CT检查(+);术后病理(+):病灶抗酸杆菌(+)	抗结核药物治疗5个月后手术,术后给予二线抗结核药物治疗