Abstract:

Objective To explore the influencing factors of pulmonary tuberculosis in schools students in Guangzhou, in order to provide better scientific basis for schools tuberculosis prevention and control.Methods A 1:4 matched case-control study was conducted. The case group was composed of 116 pulmonary tuberculosis patients in 4 schools in Guangzhou during tuberculosis screening and registered in our center from January 2013 to December 2014, and each case selected 4 controls of healthy students with the same gender, age, faculty and hostel. All the 464 controls had neiher pulmonary suspicious lesions nor symptoms of respiratory tract infection in the past two weeks. Self-designed questionnaire with guidance from tuberculosis professionals was used to investigate the two groups face-to-face. The survey included the basic information and 21 indicators such as BMI, parental educational level, percapita family income, life behavior, dietary status, psychosocial and social factors, history of exposure to tuberculosis, and vaccination history of Bacille Calmette Guerin, et.al. To explore the influencing factors of pulmonary tuberculosis prevalence, Chi-square test was used for univariate analysis, and then a total of 21 indicators were analyzed using the conditional logistic regression model for multivariate analysis.Results Multivariate conditional logistic regression analysis showed that history of exposure to tuberculosis (OR(95%CI): 5.44 (1.30-22.71), P=0.020), smoking (OR (95%CI):14.30 (3.86-51.76, P<0.001), introversion personality (OR (95%CI): 5.99 (2.67-13.44), P<0.001), negative life events (OR(95%CI): 3.73 (1.19-11.73), P=0.024) were risk factors of pulmonary tuberculosis prevalence in schools students, living expense level ≥RMB 800 yuan per month (OR (95%CI):0.06 (0.02-0.23), P<0.001)and the frequence of vegetables and fruits intake ≥7 times every 3 times every week as reference, OR (95%CI): <0.01 (<0.01-0.06), P<0.001) were protective factors of the pulmonary tuberculosis prevalence in schools students, respectively.Conclusion History of exposure to tuberculosis, smoking, introversion personality and negative life events could increase the risk while high living expenses level and increased intake of vegetables and fruits might reduce the risk of pulmonary tuberculosis prevalence in schools students.

Key words: Schools, Students, Tuberculosis, pulmonary, Case-control studies, Factor analysis, statistical, Causality