Abstract:

Objective: To systematically analyze the therapeutic effect of operation combined with irrigation and drainage of focus lesion in the treatment of spinal tuberculosis. Methods: Two researchers independently conducted a literature search in China National Knowledge Infrastructure, Wanfang Date, VIP, PubMed, EMbase and Cochrane Library, and collected randomized controlled trials (RCTs) and retrospective studies on the treatment of spinal tuberculosis by surgery combined with catheter irrigation and drainage. The language was limited to Chinese and English. The two researchers independently evaluated the quality of each study, and extracted the preoperative and postoperative data of visual analogue score (VAS), Cobb angle, Erythrocyte sedimentation rate (ESR), C-reactive protein into an electronic baseline table which were analyzed and synthesized by Review Manager 5.4 software to evaluate the effectiveness of this surgical technique in the treatment of spinal tuberculosis. Results: A total of 7 studies with 191 patients were eventually included in the analysis. Meta-analysis results showed that: the mean difference between postoperative VAS scores and preoperative VAS scores was 5.33 (95%CI: 4.11-6.55); The mean difference between Cobb angle after operation and Cobb angle before operation was 14.47° (95%CI: 11.32°-17.61°); The difference between postoperative ESR and preoperative ESR was 40.20 mm/1 h (95%CI: 27.80-52.60); The mean difference between postoperative C-reactive protein and preoperative C-reactive protein was 30.44 mg/L (95%CI: 12.12-48.76). Conclusion: Operation combined with irrigation and drainage had a good therapeutic effect in the treatment of spinal tuberculosis, could effectively reduce the pain level of patients and improve the physical deformity and physical condition of patients, thus to improve the cure rate.

Key words: Tuberculosis,spinal, Recurrence, Punctures, Drainage, Surgical procedures, Treatment outcome, Meta-Analysis