Research progress on the anti-Mycobacterium tuberculosis activity of sitafloxacin

doi:10.19982/j.issn.1000-6621.20250295

Abstract

Abstract:

The global tuberculosis epidemic remains severe, and China continues to be classified among the tuberculosis high-burden countries. Conventional fluoroquinolones are increasingly limited by cross-resistance and adverse-event profiles. Sitafloxacin, distinguished by its dual-target mechanism and good tissue penetration (The ratio of alveolar lining fluid concentration to plasma concentration is 54%), exhibits potent bactericidal activity against multidrug-resistant, rifampicin-resistant, pre-extensively drug-resistant, and extensively drug-resistant Mycobacterium tuberculosis strains. Comparative studies indicate that its early bactericidal activity surpasses that of levofloxacin and moxifloxacin, while its safety profile remains acceptable. Notably, the first documented case of pre-extensively drug-resistant tuberculosis has been successfully treated with sitafloxacin-based regimens. This review synthesizes recent advances in the use of sitafloxacin for tuberculosis therapy, aiming to provide an evidence-based reference for its clinical application.

Key words: Sitafloxacin, Tuberculosis, Antitubercular agents, Review literature as topic

CLC Number:

Wang Xueyu, Chu Naihui, Nie Wenjuan. Research progress on the anti-Mycobacterium tuberculosis activity of sitafloxacin[J]. Chinese Journal of Antituberculosis, 2026, 48(2): 299-303. doi: 10.19982/j.issn.1000-6621.20250295

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