Abstract: Nowadays,the prevalence and incidence of tuberculosis are on the rise in the whole world.However,the maximum protection of the only used tuberculosis vaccine-Bacilli Calmette-Guérin is limited.Therefore,it is very urgent to research and develop a new effective vaccine.Ag85 cantigen 85 complex has received a great attention in the field of new vaccine against tuberculosis because it can enhance experimental animals’immunity.This article introduced some achievements about Ag85 complex vaccines.The results showed that researchers have demonstrated that the protection of a few vaccines exceed that of traditional BCG. As a priming vaccine,it is safety and effective for newborns, children and  youngsters.  As a booster regimen to adults,it can enhance the anti-tuberculosis ability. Moreover, the vaccine combined with chemotherapy can improve the immunity and curative effect.But it needs more clinical trical evidence to demonstrate wether if it could replace traditional BCG.

Key words: Acyltransferases, Antigens, bacterial, Bacterial proteins, Vaccines, subunit, BCG vaccine, Vaccines, DNA, Tuberculosis/prevention &, control