Abstract: Objective To analyse and evaluate the trend of antituberculosis drugs resistance for in-patient pulmonary tuberculosis for a better job of tuberculosis control.Methods To collect in-patient cases in different years, i.e.1980～1981,1990～1991,1997～1998.The trend of drug resistance was analysed.Results The prevalence of primary drug resistance was 24.6%,35.1% and 38.3% respectively in three periods.The prevalence of primary MDR-TB drug resistance was 3.5%,6.1% and 12.3% respectively.The prevalence of acquired drug resistance was 81.0%,65.8% and 74.4% respectively.The prevalence of acquired MDR-TB drug resistance was 11.5%,16.6% and 34.9% respectively.The perevalence of primary and acquired MDR-TB drug resistance was increasing but the prevalance of acquired drug resistance was almost steadily decreasing.Conclusion The key of controlling drug resistance is to implement NTP,to standardize chemotherapy regimens,to implement DOTS,and to improve the evaluation work of drug resistance.

Key words: Tubtrculosis,pulmonary/prevention and control, Drug resistance