Abstract: Objective To determine the drug resistance on Mycobacterium fortuitum .Methods 29 strains M.fortuitum of clinical isolates had been identified by conventional and molecular biological identification Methods were uesed for susceptibility tests to the main anti-tuberculosis drugs.Results The isolates were susceptible to OFLX and LVFX,resisted to all single anti-tuberculosis drug;The Results of malti-drugs susceptibility test showed that the isolates resistant to two or three anti-tuberculosis drugs at the low concentration but susceptible at the high concentrat .Conclusion It will be possible toget higher cure rate,if the clinical cases should been treated with susceptible antibiotics in combination with anti-tuberculosis drugs in synergism.

Key words: Mycobacteria, fortuitum, Drug resistance