Research progress of heme oxygenase-1 in tuberculosis

doi:10.19982/j.issn.1000-6621.20260205

Abstract

Abstract:

Heme oxygenase-1 (HO-1) is a key enzyme in heme metabolism. It plays a critical regulatory role in processes such as oxidative stress, immune response, and cellular metabolism. In recent years, HO-1 has become a focal point of tuberculosis research. Starting from the biological characteristics of HO-1, this article systematically elucidates its dual role in the development of pulmonary tuberculosis. On this basis, we further explore the predictive value of HO-1 as a potential biomarker for tuberculosis diagnosis, treatment guidance, and prognosis assessment. The article also reviews recent advances in host-directed therapeutic strategies targeting HO-1, including pharmacological interventions and their synergistic effects with existing anti-tuberculosis drugs. Finally, we analyze the current controversies and key challenges in the field and provide future perspectives. The aim is to offer a theoretical foundation and research directions for the development of novel diagnostic and therapeutic approaches, as well as for the improvement of tuberculosis prevention and control practices.

Key words: Heme oxygenase-1, Tuberculosis, pulmonary, Host-directed therapy

CLC Number:

R521

Meng Die, Zhu Liang. Research progress of heme oxygenase-1 in tuberculosis[J]. Chinese Journal of Antituberculosis, 2026, 48(9): 1415-1421. doi: 10.19982/j.issn.1000-6621.20260205

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