Analysis of latent tuberculosis infection prevalence and its related factors in 1007 patients with diabetes mellitus

doi:10.19982/j.issn.1000-6621.20260050

Abstract

Abstract:

Objective: To understand the prevalence of latent tuberculosis infection (LTBI) and its related factors in patients with diabetes mellitus, and to provide evidences for pulmonary tuberculosis prevention and control in this high-risk group. Methods: A cross-sectional survey was conducted for 1007 diabetes mellitus patients underwent LTBI screening in Anji County, Zhejiang Province from April 2024 to December 2024. The data of LTBI screening and diabetes mellitus patients were sourced from the local regional cloud medical information system. With the interferon gamma release assay (IGRA) for detection, the prevalence of LTBI in diabetes mellitus patients was described and related factors were analyzed with the multivariate logistic regression model. Results: Among 1007 diabetes mellitus patients, 149 were positive for IGRA, and no active pulmonary tuberculosis was found. The latent tuberculosis infection rate was 14.8%. The results of multivariate analysis showed that age ≥60 years (OR=1.788, 95%CI: 1.159-2.760), daily smoking ≤20 cigarettes (OR=1.694, 95%CI: 1.004-2.857), >20 cigarettes (OR=2.650, 95%CI: 1.079-6.506), and average psychological adjustment status (OR=1.674, 95%CI: 1.176-2.384) were related factors for LTBI in diabetes mellitus patients. Conclusion: The LTBI rate in diabetes mellitus patients is at a relatively high level, and age, smoking, and psychological status are related factors. It is suggested that active screening of pulmonary tuberculosis should be emphasized in the management of diabetes, and key interventions should be carried out for the elderly, smokers and those with poor mental status.

Key words: Diabetes, Tuberculosis, Mycobacterium infection, Factor analysis, statistical

CLC Number:

R521

You Jicun, Tian Lei, Wang Lingyan, Yang Zhongrong, Shen Jianyong, Chen Bin. Analysis of latent tuberculosis infection prevalence and its related factors in 1007 patients with diabetes mellitus[J]. Chinese Journal of Antituberculosis, 2026, 48(7): 965-971. doi: 10.19982/j.issn.1000-6621.20260050

Figures/Tables 3

References 26

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项目	筛查患者例数	潜伏感染例数	潜伏感染率(%)	χ²值	P值
性别				3.147	0.076
男性	420	72	17.1
女性	587	77	13.1
年龄(岁)				4.726	0.030
<60	284	31	10.9
≥60	723	118	16.3
文化程度				0.390	0.532
小学及以下	660	101	15.3
初中及以上	347	48	13.8
民族				0.217	0.641
汉族	997	147	14.7
少数民族	10	2	20.0
职业				0.402	0.526
农民	883	133	15.1
非农民	124	16	12.9
婚姻				0.134	0.714
有配偶	869	130	15.0
无配偶	138	19	13.8
居住地				0.078	0.780
街道	314	45	14.3
乡镇	693	104	15.0
高血压				0.560	0.454
是	683	105	15.4
否	324	44	13.6
中心性肥胖				0.019	0.891
是	458	67	14.6
否	549	82	14.9
日吸烟量(支)				8.477	0.014
0	847	114	13.5
≤20	131	27	20.6
>20	29	8	27.6
日饮酒量(g)				-	0.349^a
0	770	114	14.8
≤250	223	35	15.7
>250	14	0	0.0
目前心理调整状态				7.833	0.005
良好	585	71	12.1
一般	422	78	18.5
目前遵医行为				2.509	0.113
良好	540	71	13.1
一般	467	78	16.7
并发症				3.113	0.078
无	981	142	14.5
有	26	7	26.9
服药(糖尿病药物)依从性				2.567	0.109
规律	773	122	15.8
不规律	234	27	11.5
随访(糖尿病随访)分类				0.830	0.362
控制不满意	432	69	16.0
控制满意	575	80	13.9
BMI(kg/m²)				3.488	0.322
<18.5	13	4	30.8
18.5~23.9	418	56	13.4
24.0~27.9	405	63	15.6
≥28	171	26	15.2

变量	赋值
性别	男性=1;女性=2
年龄	<60岁=1;≥60岁=2
文化程度	小学及以下=1;初中及以上=2
民族	汉族=1;少数民族=2
职业	农民=1;非农民=2
婚姻	有配偶=1;无配偶=2
居住地	街道=1;乡镇=2
高血压	是=1;否=2
中心性肥胖	是=1;否=2
日吸烟量	0支=1;≤20支=2;>20支=3
日饮酒量	0g=1;≤250g=2;>250g=3
目前心理调整状态	良好=1;一般=2
目前遵医行为	良好=1;一般=2
并发症	无=1;有=2
服药(糖尿病药物)依从性	规律=1;不规律=2
随访(糖尿病随访)分类	控制不满意=1;控制满意=2
体质量指数	<18.5kg/m²=1;18.5~23.9kg/m²=2;24.0~27.9kg/m²=3;≥28kg/m²=4
检测结果	阴性=0;阳性=1

变量	β值	s${}_{\overline{x}}$值	Wald χ²值	P值	OR值	95%CI值
变量	β值	s${}_{\overline{x}}$值	Wald χ²值	P值	OR值	下限	上限
性别
男性
女性	-0.164	0.204	0.644	0.422	0.849	0.569	1.266
年龄(岁)
<60
≥60	0.581	0.221	6.891	0.009	1.788	1.159	2.760
日吸烟量(支)
0
≤20	0.527	0.267	3.901	0.048	1.694	1.004	2.857
>20	0.975	0.458	4.521	0.033	2.650	1.079	6.506
目前心理调整状态
良好
一般	0.515	0.180	8.167	0.004	1.674	1.176	2.384
并发症
无
有	0.786	0.462	2.896	0.089	2.195	0.888	5.428
常量	-2.476	0.263	88.370	0.000	0.084