Abstract:

Experimental pulmonary tuberculosis is different from clinical pulmonary tuberculosis and its pathological changes have its own characteristics. Pathology tuberculosis from animal models are varied. The differences in laboratory animal species and strain, tuberculosis strain, infection dose and challenge route result in great differences in pathology, and the related research results are inconsistent. This article summarizes experimental pulmonary tuberculosis, including animal model, its occurrence and development, lesion type, scoring of tuberculosis lesion and effectiveness evaluation of anti-tuberculosis drugs and vaccines, especially the perivasculitis/periangitis and peribronchiolitis in very early stage after tuberculosis infection. The pathological characteristics of pulmonary tuberculosis in multiple experimental animals are illustrated, such as mice, guinea pigs, goats and non-human primates. A new classification method is proposed in this article according to the characteristics of the subsequent pathological lesion after tuberculosis infection and these types consist of not only nodules, necrosis, tuberculous pneumonia, cavities and calcification/mineralization, but also lung abscess, emphysema, lung congestion, etc. Interstitial pneumonia (interstitial fibrosis) are also included as the lesion types of experimental pulmonary tuberculosis.

Key words: Tuberculosis,pulmonary, Animals,laboratory, Classification, Pathologic processes, Models,animal