Abstract: ObjectiveTo assess the clinical efficacy of combination regimens with Levofloxacin(LVFX) in retreatment of pulmonary tuberculosis. MethodsWe searched CBM, CNKI, Wan Fang Digitalization Periodical, and Wei Pu Chinese technology periodical from 1994 to 2006 for randomized controlled trials(RCTs), which were enrolled according to the criteria for inclusion and exclusion, the quality were evaluated and meta-analysis performed by RevMan4.2.7 software. ResultsWe found 8 trials including 791 patients with poor qualities. The meta-analysis showed that there were statistically significant differences on the rates of sputum negative and radiographic improvement between containing Levofloxacin group and control group (OR 3.70, 95% CI 2.59 to 5.27, and OR3.10, 95% CI 2.25 to 4.28). The rate of cavities closure in the study group maybe higher than that of the control(OR 2.41, 95% CI 1.50 to 3.89, RR 1.63, 95% CI 0.99 to 2.68) There was no difference on side effects(OR 0.94,95% CI 0.58 to 1.53). ConclusionsSo far, there are a few evidences to support the result, which the clinical efficacy on the rates of sputum negative and the radiographic improvement in the study group is better than that of the control.Due to few studies, potential publication bias, and low quality of trails, we could not draw reliable conclusions from the present data. High quality RCTs should be performed further.

Key words: Tuberculosis,pulmonary/drug therapy, Ofloxacin, Meta-analysis