Abstract: ObjectiveTo evaluate the feasibility, clinical efficacy and treatment value of interventional treatment under CT-guided percutaneous puncture for severe cavitary pulmonary tuberculosis.MethodsThirty-two patients with severe cavitary pulmonary tuberculosis were randomly assigned to a treatment group and a control group. All patients received chemotherapy with 3VHPThZAk/15VPaTh.Meanwhile,patients in the treatment group were given interventional treatment with administration of antituberculosis agents under CT-guided percutaneous puncture.ResultsAt the end of the course, the rates of sputum negative and foci absorption were,75.0% (12/16)and 62.5% (10/16)in the treatment group,respectively, which were higher than those of the control with statistical significance(P<0.05).After 3 months treatment，the rate of sputum negative was 56.3% (9/16), which was higher than that of the control（31.3%，P<0.05).There was no significant difference in cavities closure and cavities shrunk between two groups(P>0.05),the closure rate of smaller thin-walled cavity and caseous cavity were hige. The rate of air-fluid level in cavity was 9.1% in the treatment group, which was lower than that of the control(80%, P<0.01). ConclusionsThe interventional treatment under CT-guided puncture for severe cavitary pulmonary tuberculosis is a new method.It has the same therapeutic efficacy compared with other interventional treatment, icluding the role of cleaning up cavity,converting sputum negative, promoting foci absorption, and shrunking and closing cavity.It is safe, minimally invasive, less painful, low-cost, and no side effect.This therapy will play an important role in controlling the origin of infection and tuberculosis epidemic. It is Worth to be applied clinically.

Key words: Tuberculosis,pulmonary/drug therapy, Injections,intralesional, Tomography,x-ray computed