Optimum cutoff value of the sICAM-1, sIL-2R level for the diagnosis of the pulmonary tuberculosis

Chinese Journal of Antituberculosis ›› 2009, Vol. 31 ›› Issue (4): 181-184.

Optimum cutoff value of the sICAM-1, sIL-2R level for the diagnosis of the pulmonary tuberculosis

Zhang Jin¹, Hong Zhiqiang², Huang Huiliang², Cui Xiwen², Shen Yueping³

1.The first people’s hospital of Kunshan, Jiangsu Province, Kunshan 215300, China;2.The center for disease control and prevention of Kunshan, Jiangsu Province, Kunshan 215301, China;3.The Radiomedicine and public health institute of Suzhou University, Jiangsu Province, Suzhou 215325, China

Online:2009-04-10 Published:2011-11-03

Abstract

Abstract: ObjectiveTo explore the correlation between the serum level of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble interleukin-2 receptor (sIL-2R) in the smear-positive, -negative patients with pulmonary tuberculosis (TB) and health control, and to develop the optimum cutoff values of sICAM-1 and sIL-2R for the diagnosis of the TB patients. MethodELISA assay was used to measure the serum level of sICAM-1, sIL-2R in 97 newly diagnosed TB cases (containing 53 smear-positive cases, 44 smear-negative cases) aged 20 to 60 years old and being treated in Kunshan first people hospital and the township-level hospitals, Jiangsu province and 93 health controls matched by ages (±3 yrs) and sex. The pearson correlation coefficient r was estimated between the sICAM-1 and sIL-2R level among the smear-positive, smear-negative and control groups. ROC curve was used to explore the optimum cutoff value of sICAM-1, sIL-2R for the diagnosis of the TB. Resultsthe serum level of sICAM-1 was positively associated with level of sIL-2R in the smear-negative cases（r=0.4639, P=0.0017）. No significant linear correlations were found between the two indexes among the smear-positive TB patients and control population (r₁=0.0472, P=0.7397, r₂=-0.0077, P=0.9419). When the cutoff value of sICAM-1 level was higher than 364.04ng/ml, its sensitivity and specificity for the diagnosis of TB were 83.0% and 83.9%, respectively. For sIL-2R with cutoff value lower than 2.49ng/ml, the sensitivity and specificity were 63.9% and 64.8%, respectively. ConclusionThe sICAM-1 level higher than 364.04ng/ml could be regarded as the clinical diagnosis reference value for TB.

Key words: tuberculosis,pulmonary/diagnosis, intercellular adhesion molecule-1, receptors,interleukin-2

Zhang Jin¹, Hong Zhiqiang², Huang Huiliang², Cui Xiwen², Shen Yueping³. Optimum cutoff value of the sICAM-1, sIL-2R level for the diagnosis of the pulmonary tuberculosis[J]. Chinese Journal of Antituberculosis, 2009, 31(4): 181-184.

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