Abstract: Objective To discusses the change of ECM in the pulmonary tuberculosis patient and the effect of Huang Qi and salvia miltiorrhiza in its prevention.Methods 106 pulmonary tuberculosis patients were divided into group A with 55 cases and group B with 51 cases.Based on the anti-tuberculosis treatment,group A added Huang Qi and salvia miltiorrhiza.Simultaneously,50 healthy persons were recruited in the control group.HA,LN,PⅢP and C-Ⅳ were examined before and after the treatment.The blood serum HA,LN,PⅢP and C-Ⅳ,sputum conversion rate and the absorption of the focus in the lung were compared between the two groups.Results Before the treatment,the HA,LN and C-Ⅳ were significantly higher in the 106 pulmonary tuberculosis patients than the control group(P＜0.05).After the treatment,the HA,LN and C-Ⅳ were lower in group A than those in group B(P＜0.05).The following indicators were better in group A than those in group B,including sputum conversion rate at early stage,the absorption rate of the focus in the lung,the improvement of the lung function changes and the improvement of the main symptoms(P＜0.05 or P＜0.01).Conclusion ECM plays an important role in the progress of pulmonary tuberculosis,Huang Qi and salvia miltiorrhiza have active effect on preventing and reversing the pulmonary fibrosis.

Key words: Pulmonary fibrosis, Pulmonary tuberculosis/prevention and control, Huang Qi, Salvia miltiorrhiza