Abstract: Objective To study the change of cardiopulmonary function and life quality of patients with giant pulmonary bulla before and after the treatment with encheiresis in pulmonary bulla and negative pressure drainage(combined) with artificial pneumoperitoneum.Methods Eighteen giant pulmonary bulla patients were included.Measurement on their pulmonary function and 6一minute walk distance (6MWD) before and after treatment were conducted. Their dyspnea grade and life quality were assessed with the modified dyspnea scale of English Medical Research Council and short form 36 health survey questionnaire (SF-36) of American Medical Outcomes. Re-sults After the treatment, FVC，FEV!, MVV and 6MWD were all enhanced (P<0.01); RV,TLC and RV/ TLV were all decreased ( P<0.01)； dyspnea grade declined (P<0.01)； SF-36 score was improved (P<0.05, P<0.01). Conclusion The therapy of encheiresis in pulmonary bulla and negative pressure drainage combined with artificial pneumoperitoneum can effectively improve patient's cardiopulmonary function and life quality.

Key words: Giant pulmonary bulla, Negative pressure drainage, Artificial pneumoperitoneum, Cardiopul-monary function, Life quality