Abstract: Objective To probe into the drug resistance situation in the initial and acquired drug resistance PTB(pulmonary tuberculosis),and therapeutic efficacy on their complement of standard short course chemotherpy.To provide the reference to supervision and treatment for them. Method The objeets of this study were TB cases who have been taken in the project for drug resistance surveillance and completed the full course of treatment in Guangdong and Zhejiang provinces.The proportion method for drug susceptibility was used in this study.The drug resistance condition and treatment effection of the 225 patients who have completed the standard short-course chemotherapy were analysed. Results Of the 149 initials drug resistance patients,87 were single drug resistance patients,and 62 were multi-drug resistance patients.Of the 76 acquired drug resistance patients,38 were single drug resistance patients,and 38 were multi-drug resistance patients.The cure rate of initials single drug resistance patients was 94.3%;The cure rate of multi-drug resistance patients was 88.7%;The cure rate of single-drug resistance and multi-drug resistance for the acquired patients were 92.1% and 63.2% respectively. Conclusion The result shows that the short course chemotherapy could achieve good Results for single drug resistance patients.But it is not satisfied for multi-drug resistance patients,especially for the acquired ones.The treatment outcome should be evaluated with chest X-Ray,tubercle bacillus culture,and so on.The national PTB drug-resistance baseline survey should be organized all around the country,and the mechanism of drug-resistance TB should be paid more attentions,especially the treatment regiment of the multi-drug resistance PTB.

Key words: Pulmonary tuberculosis/chemotherapy, Drug resistance,bacteria, Zhejiang province, Guangdong province